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药物化学

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刘异凡博士-副教授

发布时间:2016-10-12   浏览次数:0

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刘异凡,女,汉族,河北石家庄人。2009年本科毕业于江南大学(211)应用化学专业,2012年于大连理工大学(985)获得精细化工(应用化学)硕士学位,并获得辽宁省优秀硕士毕业生称号, 2018年毕业于韩国梨花女子大学,获得有机化学博士学位。在硕导赵建章教授和博导Juyoung Yoon教授指导下,研究方向为1)长寿命三重态化合物的设计合成及其在上转换、氧传感、敏化单线态氧等方面的应用;2)小分子荧光探针对重要生物分子的检测及成像。

2018年9月入职best365官网登录入口药物化学教研室任讲师,2019年11月晋升为副教授,2020年受聘为学术型和专业型硕士研究生导师。主讲课程包括药学本科《有机化学》、《化工原理》、《药物合成反应》及研究生《新药开发与现代化研究》。

目前的科研方向为可用于疾病诊断和治疗的双效小分子化合物的设计、合成及应用。主持的在研项目有:2019年河北省引进留学人员资助项目,2019年best365官网登录入口春雨计划优秀青年基金,2020年河北省生物医药联合基金培育项目,2021年河北省教育厅青年拔尖人才项目,课题总经费53万元。目前以第一作者身份发表SCI论文14篇,其中JCR一区论文5篇。

科研业绩

1. Energy-Level Control via Molecular Planarization and Its Effect on Interfacial Charge-Transfer Processes in Dye-Sensitized Solar Cells. J Phys. Chem. C. 2019; 123; 13531-13537. (JCR Q2, IF:4.309)

2. Rhodamine derivatives bearing thiourea groups serve as fluorescent probes for selective detection of ATP in mitochondria and lysosomes. Sensor Actuat B- Chem. 2019; 281: 350-358. (JCR Q1, IF:6.393)

3. A new kind of rhodamine-based fluorescence turn-on probe for monitoring ATP in mitochondria. Sensor Actuat B- Chem. 2018; 265: 429-434. (JCR Q1, IF:6.393)

4. Fluoride ion activated CO2 sensing using sol-gel system. Dyes and Pigments. 2017; 139: 658-663. (JCR Q2, IF:4.018)

5. Fluorescent and colorimetric chemosensors for anions, metal ions, reactive oxygen species, biothiols, and gases. B KOREAN CHEM SOC. 2016; 37: 1661-1678. (IF:0.60)

6. Pyrene based fluorescent probes for detecting endogenous zinc ions in the cells. Dyes and Pigments. 2015; 113: 372-377. (JCR Q2, IF:4.018)

7. A bispyrene derivative as a selective fluorescent probe for RNA. Chem. Comm. 2014; 50: 2505-2507. (JCR Q1, IF:6.164)

8. New iridium complexes with two pre-organized urea groups and thiourea groups as phosphorescent chemosensors for H2PO4- and chiral carboxylates. Dyes and Pigments. 2014; 100: 241-246. (JCR Q2, IF:4.018)

9. A new phosphorescent chemosensor bearing Zn-DPA sites for H2PO4-. Dyes and Pigments. 2014; 106: 20-24. (JCR Q2, IF: 4.018)

10. Visible light-harvesting perylenebisimide-fullerene (C60) dyads with bidirectional “ping-pong” energy transfer as triplet photosensitizers for  photooxidation of 1,5-dihydroxynaphthalene. Chem. Comm. 2012; 48: 3751-3753. (JCR Q1, IF: 6.164)

11. BF2-bound chromophore-containing N^N Pt(II) bisacetylide complex and its application as sensitizer for triplet-triplet annihilation based upconversion. RSC Advances. 2012; 2: 1061-1067. (JCR Q2, IF:3.049)

12. Ratiometric luminescent molecular oxygen sensors based on uni-luminophores of C^N Pt(II)(acac) complexes that show intense visible-light absorption and balanced fluorescence/ phosphorescence dual emission. Chem. Comm. 2011; 47: 11471-11473. (JCR Q1, IF: 6.164)

13. Accessing the long-lived near-IR-emissive triplet excited state in naphthalenediimide with light-harvesting diimide platinum(II) bisacetylide complex and its application for upconversion. Dalton Trans. 2011; 40: 9085-9089. (JCR Q2, IF:4.052)

14. Enantioselective recognition of tartaric acids with ethynylated carbazole-based chiral bisboronic acid chemosensors with improved response at acidic pH. J. Fluoresc. 2011; 21: 1979-1986. (JCR Q3, IF:1.913)


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