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药物化学

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石晓伟博士-教授

发布时间:2016-10-12   浏览次数:0

石晓伟,汉族,中共党员,河北乐亭人。2004年毕业于best365官网登录入口药学专业,同年留校任教至今,先后获药物化学硕士学位、药理学博士学位。现为best365官网登录入口药物化学教研室副教授,硕士研究生导师,河北省药学会药学科普专业委员会委员、中药分析委员会委员,河北省药物与卫生技术综合评估学会药品临床综合评价专业委员会委员。

主讲《药物化学》《药物设计学》两门课程,年均教学量200余课时,并于2017年与2019年获全国教育教学信息化大奖赛河北赛区高等教育组三等奖。

主要研究方向为基于药物代谢的先导化合物的发现与优化。主持河北省重点研发计划项目、河北省自然科学基金项目、河北省科技支撑计划项目、河北省高等学校科学技术研究项目等共6项,参加国家自然科学基金项目2项和河北省自然科学基金项目2项,指导本科生实验获得国家级和校级大学生创新实验项目共3项。获省级科研成果2项,获河北省科技进步奖三等奖1项、发明专利4项。在Food Chem、Anal Bioanal Chem、J Pharm Biomed Anal、J Chromatogr B、中草药、药学学报、中国医药工业杂志等国内外权威专业期刊已发表学术论文50余篇,其中以第一作者或通讯作者发表SCI论文11篇,h-index为19,引用次数800余次。

主持科研项目情况

1. 河北省重点研发计划项目,20374801D,强肝胶囊质量标准提升关键技术研究与应用,2020.06-2022.12,50万元,主持人

2. 河北省自然科学基金,H2020206067,基于ADME的新型多靶点叶酸拮抗剂的成药性研究,2020.09-2022.12,10万元,主持人

3. 河北省自然科学基金,H2017206087,LC-MS精准导向发现木果楝中新柠檬苦素及其抗肺癌活性研究,2017.01-2019.12,主持人

4. 河北省高等学校科学技术研究项目,QN2017098,基于LC-MS的抗肺癌活性木果楝柠檬苦素的大鼠体内代谢研究,2017.01-2019.12,主持人

5. 河北省高等学校科学技术研究项目,Z2012036,基于液质联用技术的欧亚旋覆花化学成分分析,2013/01-2014/12,主持

6. 河北省科技支撑计划项目,12272604,萘普西诺-羟丙基-β-环糊精包合物的研究,2012/12-2014/12,主持

发表论文代表作

1)Shi Xiaowei#, Wu Yibing, Lv Tao, Wang Yufang, Fu Yan, Sun Mengmeng, Shi Qingwen*, Huo Changhong*, Wang Qiao, Gu Yucheng. A chemometric-assisted LC-MS/MS method for the simultaneous determination of 17 limonoids from different parts of Xylocarpus granatum fruit. Analytical and Bioanalytical Chemistry, 2017, 409(19): 4669-4679. (JCR Q1, IF:3.637)

2)Shi Xiaowei#, Wang Shuang#, Qian Qi, Zhou Na, Qi Pengcheng, Mu Xiyan, Wang Qiao*. Herb–herb pharmacokinetic interaction between Glehniae radix and Ophiopogonis radix in rats using superimposed multiple product ion (SMPI) LC-HR-MS/MS. RSC Advances, 2017, 7(47): 29732-29741. (JCR Q2, IF:3.119)

3)Yao Donggui, Wang Yufang, Huo Changhong*, Wu Yibing, Zhang Manli, Li Ligeng, Shi Qingwen, Kiyota Hiromasa, Shi Xiaowei*. Study on the metabolites of isoalantolactone in vivo and in vitro by ultra performance liquid chromatography combined with Triple TOF mass spectrometry. Food Chemistry, 2017, 214: 328-338. (JCR Q1, IF:6.306)

4)Yao Donggui, Li Zhe, Huo Changhong*, Wang Yufang, Wu Yibing, Zhang Manli, Li Ligeng, Shi Qingwen, Kiyota Hiromasa, Shi Xiaowei*. Identification of in vitro and in vivo metabolites of alantolactone by UPLC-TOF-MS/MS. Journal of Chromatography B, 2016, 1033: 250-260. (JCR Q2, IF:3.004)

5)Zhou Chunhua, Su Linfei, Shang Weiding, Rong Zhihuan, Sun Mengmeng, Zhang Kai, Shi Xiaowei*, Wang Qiao. Simultaneous Determination of Eight Chemicals in Fufang Xueshuantong Capsules by LC–MS-MS with Periodic Polarity Switching. Journal of Chromatographic Science, 2015, 53(10):1757-1764. (JCR Q4, IF:1.280)

6)Shi Xiaowei#, Shang Weiding, Wang Shuang, Xue Na, Hao Yanxia, Wang Yabo, Sun Mengmeng, Du Yumin, Cao Deying, Zhang Kai*, Shi Qingwen*. Simultaneous quantification of naproxcinod and its active metabolite naproxen in rat plasma using LC–MS/MS: Application to a pharmacokinetic study. Journal of Chromatography B, 2015, (978-979): 157-162. (JCR Q2, IF:3.004)

7)Shi Xiaowei#, Zhang Kai*, Xue Na, Su Linfei, Ma Gaixia, Qi Jinlong, Wu Yibing, Wang Qiao, Shi Qingwen*. Differentiation of genuine Inula britannica L. and substitute specimens based on the determination of 15 components using LC-MS/MS and principal components analysis. Food Chemistry, 2013, 141(4): 4019–4025. (JCR Q1, IF:6.306)

8)Shi Xiaowei#, Liu Man, Zhang Min, Zhang Kerong, Liu Songchen, Qiao Shi, Shi Rui, Jiang Xijuan, Wang Qiao*. Identification of in vitro and in vivo metabolites of isoimperatorin using liquid chromatography/mass spectrometry. Food Chemistry, 2013, 141(1): 357–365. (JCR Q1, IF:6.306)

9)Shi Xiaowei#, Liu Man, Sun Mengmeng, Wang Qiao, Liu Weina, Cao Deying*. Development of a LC–ESI-MS3 method for determination of nitrendipine in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56(5): 1101-1105. (JCR Q2, IF:3.209)

10)Qiao Shi#, Shi Xiaowei#, Shi Rui, Liu Man, Liu Ting, Zhang Kerong, Wang Qiao*, Yao Meicun, Zhang Lantong. Identification of urinary metabolites of imperatorin with a single run on an LC/Triple TOF system based on multiple mass defect filter data acquisition and multiple data mining techniques. Analytical and Bioanalytical Chemistry, 2013, 405(21): 6721-6738. (JCR Q1, IF:3.637)

11)Shi Xiao-Wei#, Qi Jin-Long, Wu Yi-Bing, Fu Yan, Wang Yun-Zhi*, Zhang Di-Qun. Simultaneous quantification of six sesquiterpene lactones in Inula britannica L. by RP-LC. Chromatographia, 2008, 68(3-4):281-285. (JCR Q3, IF:1.596)

获奖情况

张恺,石晓伟,薛娜,李林,杜玉民,郭海波。2017年获得河北省科技进步奖三等奖,第2名。2017JB3010-2.


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