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药剂学

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王静博士-教授

发布时间:2016-10-29   浏览次数:0

 

 

王静,教授,best365官网登录入口副院长,药剂学博士生导师。研究方向集中于药物超分子体系的筛选、纳米材料的生物应用、基于肿瘤微环境智能响应性释放的载药体系的构建。主持国家自然科学基金、河北省自然基金多项、河北省科技厅重大支撑课题、中国博士后基金和河北省博士后基金、河北省“高校百名创新人才”支持计划研究项目。研究成果获河北省科技进步二等奖一项(第一)、三等奖一项(第一)。河北省优秀教师,河北省优秀硕士论文指导教师,best365官网登录入口优秀教师和优秀共产党员。发表第一作者和通讯作者SCI论文30余篇。

主持科研项目情况:

1. 2007-2010, 氧化铁磁性纳米微球的制备,河北医大科研骨干人才培育计划资助项目,负责人,经费1.5万。

2. 2008-2010,顺铂磁性热敏性脂质体的分子设计和组装(C2008001072),河北省自然基金面上项目负责人,经费5.0万。

3. 2009-2011,药物的单晶培养与同质异晶研究(2009148),教育厅科研计划项目,负责人,经费1.0万。

4. 2009-2011,治疗心血管疾病一类新药-间尼索地平的同质异晶研究(20090059),卫生厅科研基金项目,负责人,经费0.6万。

5. 2011-2012,河北省博士后基金重点资助:“药物共晶的分子设计和筛选”,到位经费5.0万。负责人

6. 2011-2012年,第49批中国博士后科学基金面上项目 “药物共晶设计和筛选模型的建立”,编号20110490983,到位经费3.0万,负责人。

7. 2012-2016年,科技厅科技支撑重大课题:阿折地平药物共晶的设计和筛选(12276402D),到位经费25万,负责人。

8. 2013-2015年,国家自然基金青年基金:药物分子多无定型态及其与多晶态相互转化的太赫兹谱研究(81202504),资助经费23万,负责人。

9. 2013-2015年,河北省自然科学基金,石药集团医药联合基金优先资助:亲水性抗癌药顺铂磁靶向固态脂质纳米粒的分子设计(H 2013206040),资助经费5万,负责人。

10. 2017-2019年, 河北省自然科学基金:基于顺铂不同时相联合给药磁性控释微球的设计和组装(H2017206214),资助经费:6万,负责人

11. 2017-2019年,河北省高校百名优秀创新人才支持计划(SLRC2017047),资助经费:20万。

发表论文情况(*代表通讯作者):

1. Wang J., Deng T., Dai Y.J., Study on the processes and mechanism of the formation of Fe3O4 at low temperature, J. Alloys Compounds, 2005, 390(1-2): 127-132.

2. Wang J., Deng T., Dai Y.J., Comparative study on the preparation procedures of cobalt ferrites by aqueous processing at ambient temperatures, J. Alloys Compounds, 2006, 419(1-2): 155-161.

3. Wang J., Deng T. and Yang C.Q., Synthesis of gallium bearing magnetic particles from aqueous solution: influence of mixing procedure of initial solution and the ratio of Ga/Fe, J. Alloys Compounds, 2008, 450(1-2): 276-283.

4. Wang J., Deng T., Lin Y.L., Yang C.Q., and Zhan W.H., Synthesis and characterization of CoFe2O4 magnetic particles prepared by co-precipitation method: Effect of mixture procedures of initial solution. J. Alloys Compounds, 2008, 450(1-2): 532-539.

5. Xu X.J., Wang J., Yang C.Q and Wu H.Y., Sol-gel formation of γ-Fe2O3/SiO2 nanocomposites: Effects of different iron raw material. J. Alloys Compounds, 2009, 468(1-2): 414-420.

6. Wang J., Ding L.Y. and Yang C.Q., Three concomitant polymorphs of 1: 1 4, 4′-dihydroxybenzophenone/1, 2-bis (4-pyridyl)-ethylene: applications of hydrothermal method in searching polymorphs, Cryst. Eng. Comm, 2007, 9(7): 591-594.

7. Wang J., Deng T. and Yang C.Q., Studies on the behavior of Co2+ and Zn2+ in the conversion from FeOOH to magnetite in NH3 (NaOH)-Fe2+, Co2+-H2O medium under hydrothermal conditions, Hydrometallurgy, 2008, 92(3-4): 107-114.

8. Wang J., Wu H.Y., Yang C.Q. and Lin Y.L., Room Temperature Mossbauer Characterization of Ferrites with Spinel Structure. Material Characterization, 2008, 59(12): 1716-1720.

9. Yang C.Q. and Wang J., Deliberate design of an acentric diamondoid metal-organic network, J. Solid State Chem., 2011, 184(9): 2485-2489.

10. Wang J. and Wang Y.L., 1-Diphenylmethyl-4-[3- (4-fluorobenzoyl) propyl] piperazine-1,4-diium dichloride monohydrate, Acta Cryst, 2011, 67(10): o2719-o2719.

11. Yang C.Q., Zhang Z.W., Zeng Y.L., Wang J. and Ma B.Q., Structures and characterization of m-nisoldipine polymorphs, Cryst. Eng. Comm., 2012, 14(7): 2589-2594.

12. Wang L., Yang C.Q. and Wang J.., Effects of loading procedures of magnetic nanoparticles on the structure and physicochemical properties of cisplatin magnetic liposomes, J Microencapsul, 2012, 29(8): 781-789.

13. Li D., Wang M., Yang C.Q., Wang J. and Ren G.D., Solid State Characterizations and Analysis of Stability in Azelnidipine Polymorphs, Chem.Pharm.Bull., 2012, 60(8): 995-1002.

14. Yang C.Q., Xu X.J., Wang J. and An Z.Q., Use of the Co-grinding Method to Enhance the Dissolution Behavior of a Poorly Water-Soluble Drug: Generation of Solvent-Free Drug?CPolymer Solid Dispersions, Chem.Pharm.Bull., 2012, 60(7): 837-845.

15. Liu J., Wang L., Wang J. and Zhang L.T., Simple solvothermal synthesis of hydrophobic magnetic monodispersed Fe3O4 nanoparticles, Mater Res Bull, 2013, 48(2): 416-421.

16. Yang C.Q., Ren T.K., Wang J., Wang Y.L.* and Tao X.L., Thermodynamic stability analysis of m-nisoldipine polymorphs, J.Chem.Thermodynamics, 2013, 58: 300-306.

17. Lian W.G., Lin Y.L., Wang M., Yang C.Q. and Wang J., Crystal engineering approach to produce complex of azelnidipine with maleic acid. Cryst. Eng. Comm., 2013, 15(19): 3885-3891.

18. Zhao S., Yang C.Q. and Wang J., A novel solvethemal method for the preparation of magnetic monodisperse Fe3O4 nanoparticles II: high-surface-activity ferrihydrite used as precursor, Mater Res Bull, 2013, 48(2): 416-421.

19. Lin Y.L., Yang H., Yang C.Q. and Wang J., Preparation, Characterization, and Evaluation of Dipfluzine-Benzoic Acid Co-crystals with Improved Physicochemical Properties. Pharm. Res. 2014, 31(3): 566-578.

20. Zhao S., Zhang Y.L., Han Y.Z., Wang J. and Yang J., Preparation and Characterization of Cisplatin Magnetic Solid Lipid Nanoparticles (MSLNs): Effects of Loading Procedures of Fe3O4 Nanoparticles, Pharm. Res., 2015, 32(2): 482-491.

21. Liu H., Zhang Y.L., Han Y.Z., Zhao S., Wang L., Zhang Z.X., Wang J. and Cheng J.X., Characterization and cytotoxicity studies of DPPC:M2+ novel delivery system for cisplatin thermosensitivity liposome with improving loading efficiency, Colloid Surface B, 2015, 131: 12-20.

22. Han Y.Z., Pan Y.H., Lv J., Guo W. and Wang J., Powder grinding preparation of co-amorphous β-azelnidipine and maleic acid combination: Molecular interactions and physicochemical properties, Powder Technology, 2016, 291: 110-120.

23. Yang C.Q., Lv J., Lv T., Pan Y.H., Han Y.Z., Zhao S. and Wang J., Metal ion-assisted drug-loading model for novel delivery system of cisplatin solid lipid nanoparticles with improving loading efficiency and sustained release, J. Microencapsul., 2016, 33(3): 292-298.

24. Pan Y.H., Pang W.Z., Lv J., Wang J., Yang C.Q., and Guo W., Solid state characterization of azelnidipine?Coxalic acid co-crystal and co-amorphous complexes: The effect of different azelnidipine polymorphs, J. Pharm. Biomed. Anal., 2017, 138: 302-315.

25. Pang W.Z., Lv J. Du S., Wang J.J., Wang J. and Zeng Y.L., Preparation of Curcumin-Piperazine Coamorphous Phase and Fluorescence Spectroscopic and Density Functional Theory Simulation Studies on the Interaction with Bovine Serum Albumin, Mol. Pharmaceutics, 2017, 14(9): 3013-3024.

26. Yang C.Q., Guo W., Lin Y.L., Lin Q.Q., Wang J.J., Wang J. and Zeng Y.L., Experimental and DFT simulation study of a novel felodipine cocrystal: Characterization, dissolving properties and thermal decomposition kinetics, J. Pharm. Biomed. Anal, 2018, 154: 198-206.

27. Guo W., Du S., Lin Y.L., Lu B., Yang C.Q., Wang J.. and Zeng Y.L., Structural and computational insights into the enhanced solubility of dipfluzine by complexation: salt and salt-cocrystal, New J. Chem., 2018, 42(18): 15068-15078.

28. Du S., Li W.S., Wu Y.R., Fu Y., Yang C.Q. and Wang J., Comparison of the physical and thermodynamic stability of amorphous azelnidipine and its coamorphous phase with piperazine, RSC Adv., 2018, 8(57): 32756-32764.

29. Zhu Y.Y., Jia S.P., Zheng J.F., Lin Y.L., Wu .Y.R. and Wang J., Facile synthesis of nitrogen-doped graphene frameworks for enhanced performance of hole transport material-free perovskite solar cells, J. Mater. Chem. C, 2018, 6(12): 3097-3103.

30. Zhu Y.Y., Wang J.*, A non-enzymatic amperometrac glucose sensor based on the use of graphene frameworks-promoted ultrafine platinum nanoparticle, Microchimica Acta,0026-3672, 2019, 186, 538-547


 

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